Description

Buy APAAN powder online

Buy APAAN powder online. APAAN (alpha-phenylacetoacetonitrile), 2-Phenylacetoacetonitrile is an analytical reference standard that is structurally categorized as an amphetamine precursor. APAAN (alpha-phenylacetoacetonitrile) is used to generate phenylacetone, which is then modified by the Leuckart reaction to synthesize amphetamine.

Chemical formula: C₁₀H₉NO
Molar mass: 159.187 g/mol
CAS Number: 4468-48-8

APAAN (Alpha-phenylacetoacetonitrile); A new precursor substance for the illicit production of amphetamine:
alpha-phenylacetoacetonitrile (APAAN) has become an important precursor substance for the illicit synthesis of amphetamine and its importance is further increasing.

One of the reasons for the increasing importance of APAAN is that the conversion into benzylmethylketone (BMK) can be done very easily by using a simple production method, which achieves high yields. The conversion of APAAN into BMK is predominantly performed in laboratories located in The Netherlands and Poland. Although it is widely used for illicit BMK production, from the forensic point of view there is still a lack of knowledge concerning APAAN, its purity, the different conversion processes, yields and characteristic impurities of BMK. Order Alpha-phenylacetoacetonitrile online

Methods: Here, we present a systematic forensic study of the chemistry of APAAN as a precursor substance of amphetamine. APAAN from different sources was characterized by several analytical techniques (e. g. GC/MS, LC/MS, 1H-NMR) to obtain a chemical profile of the substance and its impurities. Furthermore, model syntheses have been conducted to achieve a valid database for calculation of the yield. Therefore, the most common conversion methods were investigated. Finally, the BMK produced was analyzed by GC/MS for characteristic impurities of the synthesis. Buy APAAN online

The characterization of APAAN showed a purity range of the illicit material from 70-98%. The APAAN hydrolysis experiments were conducted using three different inorganic acids (sulphuric acid, hydrochloric acid, phosphoric acid). These experiments showed a yield that ranged from 50-75%. Finally, some characteristic BMK impurities were characterized. Buy APAAN online

Conclusion: A systematic investigation of APAAN was performed by characterizing APAAN impurities and determining BMK yields from different synthesis pathways. In addition, BMK obtained from the hydrolysis of APAAN was characterized via GC/MS. Buy APAAN (Alpha-phenylacetoacetonitrile) online

2-Phenylacetoacetonitrile. 4468-48-8. 3-Oxo-2-phenylbutanenitrile. alpha-Acetyl Phenyl Acetonitrile. Acetonitrile, phenylacetone. APAAN (alpha-phenylacetoacetonitrile)

Designation of Alpha-Phenylacetoacetonitrile (APAAN), a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine.

Since the beginning of 2011 alpha-phenylacetoacetonitrile (APAAN) has become an important precursor substance for the illicit synthesis of amphetamine and its importance isfurther increasing. APAAN (alpha-phenylacetoacetonitrile)

APAAN has been observed in seizures in The Netherlands, Poland and Germany. One of the reasons for the increasing importance of APAAN is that the conversion into benzyl methyl ketone (BMK) can be done very easily by using a simple production method, which achieves high yields.

The conversion of APAAN into BMK is predominantlyperformed in laboratories located in The Netherlands and Poland. Although it is widely used for illicit BMK production, from the forensic point of view there is still a lack of knowledge concerning APAAN, its purity, the different conversion processes, yields and characteristic impurities of BMK. APAAN (alpha-phenylacetoacetonitrile)

Methods: Here, we present a systematic forensic study of the chemistry of APAAN as a precursor substance of amphetamine. APAAN from different sources was characterized by several analytical techniques (e. g. GC/MS, LC/MS, 1 H-NMR) to obtain a chemical profile of the substance and its impurities. Furthermore, model syntheses have been conducted to achieve a valid database for calculation of the yield.

Therefore, the most common conversion methods were investigated. Finally, the BMK produced was analyzed by GC/MS for characteristic impurities of the synthesis.
Results and Discussion: The characterization of APAAN from different seizures showed a purity range of the illicit material from 70-98%. APAAN (alpha-phenylacetoacetonitrile)

The APAAN hydrolysis experiments were conducted using three different inorganic acids (sulphuric acid, hydrochloric acid, phosphoric acid). These experiments showed a yield that ranged from 50-75%. Finally, some characteristic BMK impurities were characterized. APAAN (alpha-phenylacetoacetonitrile)

Conclusion: A systematic investigation of APAAN was performed by characterizing APAAN impurities and determining BMK yields from different synthesis pathways. In addition, BMK obtained from the hydrolysis of APAAN was characterized via GC/MS. APAAN (alpha-phenylacetoacetonitrile)

A solution of sodium ethoxide is prepared from 60 g. (2.6 gram atoms) of clean sodium and 700 cc. of absolute alcohol in a 2-l. round-bottomed flask equipped with a reflux condenser. To the hot solution is added a mixture of 234 g. (2 moles) of pure benzyl cyanide and 264 g. (3 moles) of dry ethyl acetate.

The mixture is thoroughly shaken, the condenser closed with a calcium chloride tube, and the solution heated on the steam bath for two hours before standing overnight. The next morning the mixture is stirred with a wooden rod to break lumps, cooled in a freezing mixture to −10°, and kept at this temperature for two hours. The sodium salt is collected on a 6-in. Büchner funnel and washed four times on the funnel with 250-cc. portions of ether.  APAAN (alpha-phenylacetoacetonitrile)

The filter cake is practically colorless and corresponds to 250–275 g. of dry sodium salt, or 69–76 per cent of the calculated amount. The combined filtrates are placed in the freezing mixture until they can be worked up as indicated below.

The sodium salt still wet with ether is dissolved in 1.3 l. of distilled water at room temperature, the solution cooled to 0°, and the nitrile precipitated by adding slowly, with vigorous shaking, 90 cc. of glacial acetic acid, while the temperature is kept below 10°.

The precipitate is separated by suction filtration and washed four times on the funnel with 250-cc. portions of water. The moist cake weighed about 300 g. corresponds to 188–206 g. (59–64 per cent) of dry colorless α-phenylacetoacetonitrile, m.p. 87–89°, which is suitable for most purposes. APAAN (alpha-phenylacetoacetonitrile)

α-Phenylacetoacetonitrile (APAAN) is an analytical reference standard that is structurally categorized as an amphetamine precursor. APAAN is used to generate phenylacetone, which is then modified by the Leuckart reaction to synthesize amphetamine. APAAN (alpha-phenylacetoacetonitrile)

APAAN is a primary precursor for the manufacture of phenylacetone (also known as phenyl-2-propanone (P2P) or benzyl methyl ketone), methamphetamine, and amphetamine. Throughout the 1970s, methamphetamine was illicitly produced in the United States, primarily with the precursor chemical P2P.

Designation of Alpha-Phenylacetoacetonitrile (APAAN), a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone. APAAN (alpha-phenylacetoacetonitrile)